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Tapentadol is a centrally acting analgesic medication used primarily for the management of moderate to severe acute pain. It is similar in structure to tramadol but is considered to have a more potent analgesic effect.

Tapentadol works through two mechanisms: it acts as a mu-opioid receptor agonist, similar to traditional opioid analgesics like morphine, and it inhibits the reuptake of norepinephrine, a neurotransmitter involved in pain modulation. By exerting these dual mechanisms of action, tapentadol provides pain relief while potentially reducing some of the side effects associated with traditional opioid medications, such as respiratory depression and constipation.