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Tapentadol is a centrally acting opioid analgesic medication used to treat moderate to severe pain. It's available under various brand names such as Nucynta. Tapentadol works by binding to opioid receptors in the brain and spinal cord, thereby reducing the perception of pain.

One unique aspect of tapentadol is that it not only acts as an opioid agonist but also inhibits the reuptake of norepinephrine, a neurotransmitter involved in pain modulation. This dual mechanism of action may provide additional pain relief compared to traditional opioids.

Tapentadol is prescribed for the management of acute pain, such as pain following surgery, as well as chronic pain conditions like diabetic neuropathy (nerve damage caused by diabetes) or chronic lower back pain.